Dose-Dependent Effect of Flouxetine on 6-OHDA-Induced Catalepsy in Male Rats: A Possible Involvement of 5-HT1A Receptors

Dose-Dependent Effect of Flouxetine on 6-OHDA-Induced Catalepsy in Male Rats: A Possible Involvement of 5-HT1A Receptors

Purpose: Progressive loss of dopaminergic neurons of the substantia nigra pars compacta (SNc) in Parkinson’s disease (PD) leads to impairment of motor skills. Several evidences show that the role of serotonergic system in regulation of normal movement is pivotal and mediates via 5-HT1A receptors. Ou...

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Bibliographic Details
Main Authors: Safar Farajnia, Alireza Mohajjel Nayebi, Hamdolah Sharifi
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2013-02-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
Fluoxetine
6-Hydroxydopamine
Catalepsy
Rat
Online Access:http://journals.tbzmed.ac.ir/PDF/APB/Manuscript/APB-3-203.pdf

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