The Role of Cancer-Associated Fibroblasts in Prostate Cancer Tumorigenesis

The Role of Cancer-Associated Fibroblasts in Prostate Cancer Tumorigenesis

Tumors strongly depend on their surrounding tumor microenvironment (TME) for growth and progression, since stromal elements are required to generate the optimal conditions for cancer cell proliferation, invasion, and possibly metastasis. Prostate cancer (PCa), though easily curable during primary st...

Full description

Bibliographic Details
Main Authors:	Francesco Bonollo, George N. Thalmann, Marianna Kruithof-de Julio, Sofia Karkampouna
Format:	Article
Language:	English
Published:	MDPI AG 2020-07-01
Series:	Cancers
Subjects:	prostate cancer reactive stroma tumor microenvironment bone metastasis cancer associated fibroblasts
Online Access:	https://www.mdpi.com/2072-6694/12/7/1887

Similar Items

The Stroma—A Key Regulator in Prostate Function and Malignancy
by: Christina Hägglöf, et al.
Published: (2012-05-01)

The host microenvironment influences prostate cancer invasion, systemic spread, bone colonization, and osteoblastic metastasis
by: Sourik S Ganguly, et al.
Published: (2014-12-01)

Interactions between cancer cells and bone microenvironment promote bone metastasis in prostate cancer
by: Xiangyu Zhang
Published: (2019-11-01)

Tumor Microenvironment in Prostate Cancer: Toward Identification of Novel Molecular Biomarkers for Diagnosis, Prognosis, and Therapy Development
by: Hisham F. Bahmad, et al.
Published: (2021-03-01)

The role of stromal cancer-associated fibroblasts in pancreatic cancer
by: Dagny von Ahrens, et al.
Published: (2017-03-01)

Intensity of stromal changes is associated with tumor relapse in clinically advanced prostate cancer after castration therapy
by: Jian-Ping Wu, et al.
Published: (2014-10-01)

The Effects of Resveratrol on Prostate Cancer through Targeting the Tumor Microenvironment
by: Natalie Silk, et al.
Published: (2021-02-01)

Stroma Transcriptomic and Proteomic Profile of Prostate Cancer Metastasis Xenograft Models Reveals Prognostic Value of Stroma Signatures
by: Sofia Karkampouna, et al.
Published: (2020-12-01)

Stromal Androgen Receptor in Prostate Cancer Development and Progression
by: Damien A. Leach, et al.
Published: (2017-01-01)

Humanization of the Prostate Microenvironment Reduces Homing of PC3 Prostate Cancer Cells to Human Tissue-Engineered Bone
by: Jacqui A. McGovern, et al.
Published: (2018-11-01)

Increased expression of cancer-associated fibroblast markers at the invasive front and its association with tumor-stroma ratio in colorectal cancer
by: Tessa P. Sandberg, et al.
Published: (2019-03-01)

Rhabdomyosarcoma Cells Produce Their Own Extracellular Matrix With Minimal Involvement of Cancer-Associated Fibroblasts: A Preliminary Study
by: Stefania D’Agostino, et al.
Published: (2021-01-01)

Research Progress of Tumor Microenvironment and Prostate Cancer Bone Metastasis
by: MENG Jie, et al.
Published: (2018-08-01)

The Role of Cancer-Associated Fibroblasts in Tumor Progression
by: Rushikesh S. Joshi, et al.
Published: (2021-03-01)

TβRIII Expression in Human Breast Cancer Stroma and the Role of Soluble TβRIII in Breast Cancer Associated Fibroblasts
by: Bojana Jovanović, et al.
Published: (2016-11-01)

Dual-mTOR Inhibitor Rapalink-1 Reduces Prostate Cancer Patient-Derived Xenograft Growth and Alters Tumor Heterogeneity
by: Federico La Manna, et al.
Published: (2020-06-01)

Role of EMT in Metastasis and Therapy Resistance
by: Bethany N. Smith, et al.
Published: (2016-01-01)

The Effects of Chemotherapeutics on the Ovarian Cancer Microenvironment
by: Mark A. Eckert, et al.
Published: (2021-06-01)

Fibroblasts as Modulators of Local and Systemic Cancer Metabolism
by: Hannah Sanford-Crane, et al.
Published: (2019-05-01)

Apoptosis in the Pancreatic Cancer Tumor Microenvironment—The Double-Edged Sword of Cancer-Associated Fibroblasts
by: Ester Pfeifer, et al.
Published: (2021-07-01)

Corrigendum: Dual-mTOR Inhibitor Rapalink-1 Reduces Prostate Cancer Patient-Derived Xenograft Growth and Alters Tumor Heterogeneity
by: Federico La Manna, et al.
Published: (2021-02-01)

Characterization of reactive stroma in prostate cancer: involvement of growth factors, metalloproteinase matrix, sexual hormones receptors and prostatic stem cells
by: Maurício Moreira da Silva Júnior, et al.
Published: (2015-10-01)

Stromal hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer
by: Zhaohui Yang, et al.
Published: (2017-01-01)

The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis
by: Issraa Shoucair, et al.
Published: (2020-09-01)

Macrophages and Fibroblasts, Key Players in Cancer Chemoresistance
by: Lucy V. Ireland, et al.
Published: (2018-10-01)

Evolution of fibroblasts in the lung metastatic microenvironment is driven by stage-specific transcriptional plasticity
by: Ophir Shani, et al.
Published: (2021-06-01)

Core–shell nanoparticles suppress metastasis and modify the tumour-supportive activity of cancer-associated fibroblasts
by: Dávid Kovács, et al.
Published: (2020-01-01)

Prostate cancer stem cells and their involvement in metastasis
by: Li, Hangwen
Published: (2010)

Dynamic Stromal Alterations Influence Tumor-Stroma Crosstalk to Promote Pancreatic Cancer and Treatment Resistance
by: Kendelle J. Murphy, et al.
Published: (2021-07-01)

Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity
by: Neus Bota-Rabassedas, et al.
Published: (2021-04-01)

Influence of Fibroblasts on Mammary Gland Development, Breast Cancer Microenvironment Remodeling, and Cancer Cell Dissemination
by: Angelica Avagliano, et al.
Published: (2020-06-01)

FGFR4 and β-Klotho in Metastatic Prostate Cancer
by: Shenefelt, Derek
Published: (2013)

Simultaneous Targeting Tumor Cells and Cancer-Associated Fibroblasts with a Paclitaxel–Hyaluronan Bioconjugate: In Vitro Evaluation in Non-Melanoma Skin Cancer
by: Barbara Bellei, et al.
Published: (2021-05-01)

Protein Kinase C beta in the tumor microenvironment promotes mammary tumorigenesis
by: Julie A Wallace, et al.
Published: (2014-04-01)

The Role of Stroma in Cholangiocarcinoma: The Intriguing Interplay between Fibroblastic Component, Immune Cell Subsets and Tumor Epithelium
by: Alessandra Gentilini, et al.
Published: (2018-09-01)

Stromal Features of the Primary Tumor Are Not Prognostic in Genetically Engineered Mice of Pancreatic Cancer
by: Marie C. Hasselluhn, et al.
Published: (2019-12-01)

Modulation of Immune Infiltration of Ovarian Cancer Tumor Microenvironment by Specific Subpopulations of Fibroblasts
by: Ji Wang, et al.
Published: (2020-10-01)

Cellular organization and molecular differentiation model of breast cancer-associated fibroblasts
by: Susann Busch, et al.
Published: (2017-04-01)

Fibroblast Growth Factor Family in the Progression of Prostate Cancer
by: Jun Teishima, et al.
Published: (2019-02-01)

Polymorphonuclear MDSCs are enriched in the stroma and expanded in metastases of prostate cancer
by: Jiling Wen, et al.
Published: (2020-07-01)