Identification of Distinct Heterogenic Subtypes and Molecular Signatures Associated with African Ancestry in Triple Negative Breast Cancer Using Quantified Genetic Ancestry Models in Admixed Race Populations

Identification of Distinct Heterogenic Subtypes and Molecular Signatures Associated with African Ancestry in Triple Negative Breast Cancer Using Quantified Genetic Ancestry Models in Admixed Race Populations

Triple negative breast cancers (TNBCs) are molecularly heterogeneous, and the link between their aggressiveness with African ancestry is not established. We investigated primary TNBCs for gene expression among self-reported race (SRR) groups of African American (AA, <i>n</i> = 42) and Eu...

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Bibliographic Details
Main Authors: Melissa Davis, Rachel Martini, Lisa Newman, Olivier Elemento, Jason White, Akanksha Verma, Indrani Datta, Indra Adrianto, Yalei Chen, Kevin Gardner, Hyung-Gyoon Kim, Windy D. Colomb, Isam-Eldin Eltoum, Andra R. Frost, William E. Grizzle, Andrea Sboner, Upender Manne, Clayton Yates
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
triple negative breast cancer
African ancestry
RNAseq analysis
oncologic pathways
disparities
Online Access:https://www.mdpi.com/2072-6694/12/5/1220

Internet

https://www.mdpi.com/2072-6694/12/5/1220

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