Relay of herpes simplex virus between Langerhans cells and dermal dendritic cells in human skin.

Relay of herpes simplex virus between Langerhans cells and dermal dendritic cells in human skin.

The mechanism by which immunity to Herpes Simplex Virus (HSV) is initiated is not completely defined. HSV initially infects mucosal epidermis prior to entering nerve endings. In mice, epidermal Langerhans cells (LCs) are the first dendritic cells (DCs) to encounter HSV, but it is CD103(+) dermal DCs...

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Main Authors: Min Kim, Naomi R Truong, Virginia James, Lidija Bosnjak, Kerrie J Sandgren, Andrew N Harman, Najla Nasr, Kirstie M Bertram, Norman Olbourne, Shailandra Sawleshwarkar, Kaylene McKinnon, Ralph C Cohen, Anthony L Cunningham
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4395118?pdf=render

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