Metformin enhanced in vitro radiosensitivity associates with G2/M cell cycle arrest and elevated adenosine-5’-monophosphate-activated protein kinase levels in glioblastoma

Metformin enhanced in vitro radiosensitivity associates with G2/M cell cycle arrest and elevated adenosine-5’-monophosphate-activated protein kinase levels in glioblastoma

It is hypothesized that metabolism plays a strong role in cancer cell regulation. We have recently demonstrated improved progression-free survival in patients with glioblastoma who received metformin as an antidiabetic substance during chemoradiation. Although metformin is well-established in clinic...

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Bibliographic Details
Main Authors: Adeberg Sebastian, Bernhardt Denise, Harrabi Semi B., Nicolay Nils H., Hörner-Rieber Juliane, König Laila, Repka Michael, Mohr Angela, Abdollahi Amir, Weber Klaus-Josef, Debus Juergen, Rieken Stefan
Format: Article
Language:English
Published: Sciendo 2017-11-01
Series:Radiology and Oncology
Subjects:
metformin
glycolysis
metabolism
gliomas
proliferation
cell cycle
Online Access:https://doi.org/10.1515/raon-2017-0042

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