Combination of immune checkpoint blockade with DNA cancer vaccine induces potent antitumor immunity against P815 mastocytoma

Abstract DNA vaccination against cancer has become a promising strategy for inducing a specific and long-lasting antitumor immunity. However, DNA vaccines fail to generate potent immune responses when used as a single therapy. To enhance their activity into the tumor, a DNA vaccine against murine P8...

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Bibliographic Details
Main Authors: Alessandra Lopes, Kevin Vanvarenberg, Špela Kos, Sophie Lucas, Didier Colau, Benoît Van den Eynde, Véronique Préat, Gaëlle Vandermeulen
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-018-33933-7