Amelanotic Signet Ring Cell Melanoma Presenting as Breast Lump- A Diagnostic Conundrum

• Main Authors: Prasath Sathiah, Debasis Gochhait, Subathra Adithan, Sandhya Umamahesweran, Priyadarshini Dehuri
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2017-08-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: lymph node; immunohistochemistry; metastasis; s100
• Online Access: https://jcdr.net/articles/PDF/10368/28774_CE(RA1)_F(T)_PF1(PG_KM_GG)_PFA(PG_SS).pdf
• ISSN: 2249-782X; 0973-709X

Amelanotic signet ring cell melanoma is one of the rare variants of malignant melanoma. Here we are presenting a case of a 58- year-old female with chief complaints of swelling in the left sternal region/breast, and right cervical region. Contrast Enhanced CT scan showed the two well circumscribed lobular mass lesions with central necrosis in the left breast. The radiologist opined the lesions as intramammary nodes. Biopsy from the larger breast mass lesion showed a tumour with cells arranged in discohesive pattern less with hetrogenos morphology. These tumour cells had a predominantly signet ring morphology along with markedly pleomorphic tumour cells and giant cells. These tumour cells were negative for pan CK and positive for S100, HMB45. So the case was diagnosed as metastatic amelanotic malignant melanoma with signet ring morphology.