Pyrrolizidine-Derived Alkaloids: Highly Toxic Components in the Seeds of <i>Crotalaria cleomifolia</i> Used in Popular Beverages in Madagascar

Pyrrolizidine-Derived Alkaloids: Highly Toxic Components in the Seeds of <i>Crotalaria cleomifolia</i> Used in Popular Beverages in Madagascar

Seeds of <i>Crotalaria cleomifolia</i> (Fabaceae) are consumed in Madagascar in preparation of popular beverages. The investigation of extracts from the seeds of this species revealed the presence of high amounts of alkaloids from which two pyrrolizidine-derived alkaloids were isolated....

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Bibliographic Details
Main Authors: Anjaramampionona Henintsoa Duvale Solofomalala, Clara Fredeline Rajemiarimoelisoa, Randriamampianina Lovarintsoa Judicael, Hanitra Ranjana Randrianarivo, Danielle Aurore Doll Rakoto, Victor Louis Jeannoda, Ahcène Boumendjel
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
<i>Crotalaria</i>
Fabaceae
traditional use
pyrrolizidine
alkaloids
usaramine
Online Access:https://www.mdpi.com/1420-3049/26/11/3464
Description
Summary:Seeds of <i>Crotalaria cleomifolia</i> (Fabaceae) are consumed in Madagascar in preparation of popular beverages. The investigation of extracts from the seeds of this species revealed the presence of high amounts of alkaloids from which two pyrrolizidine-derived alkaloids were isolated. One of them was fully characterized by spectroscopic and spectrometric methods, which was found to be usaramine. Owing to the high toxicity of these alkaloids, issuing a strong warning among populations consuming the seeds of <i>Crotalaria cleomifolia</i> must be considered.
ISSN:1420-3049

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