The Importance of Functional Tests in Personalized Medicine

• Main Authors: R. Jay Widmer, Amir Lerman
• Format: Article
• Language: English
• Published: Rambam Health Care Campus 2013-04-01
• Series: Rambam Maimonides Medical Journal
• Subjects: Cardiovascular disease; endothelial function; individualized medicine
• Online Access: http://rmmj.org.il/Pages/ArticleHTM.aspx?manuId=274

Cardiovascular disease is the most prevalent disease mainly in the Western society and becoming the leading cause of death worldwide. Standard methods by which healthcare providers screen for cardiovascular disease have only minimally reduced the burden of disease while exponentially increasing costs. As such, more specific and individualized methods for functionally assessing cardiovascular threats are needed to identify properly those at greatest risk, and appropriately treat these patients so as to avoid a fate such as heart attack, stroke, or death. Currently, endothelial function testing—in both the coronary and peripheral circulation—is well established as being associated with the disease process and future cardiovascular events. Improving such testing can lead to a reduction in the risk of future events. Combining this functional assessment of vascular fitness with other, more personalized, testing methods should serve to identify those at the greatest risk of cardiovascular disease earlier and subsequently reduce the affliction of such diseases worldwide.