Glycyrrhizin Inhibits PEDV Infection and Proinflammatory Cytokine Secretion via the HMGB1/TLR4-MAPK p38 Pathway

Glycyrrhizin Inhibits PEDV Infection and Proinflammatory Cytokine Secretion via the HMGB1/TLR4-MAPK p38 Pathway

Our previous study showed that glycyrrhizin (GLY) inhibited porcine epidemic diarrhea virus (PEDV) infection, but the mechanisms of GLY anti-PEDV action remain unclear. In this study, we focused on the anti-PEDV and anti-proinflammatory cytokine secretion mechanisms of GLY. We found that PEDV infect...

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Bibliographic Details
Main Authors: Ruyi Gao, Yongshuai Zhang, Yuhui Kang, Weiyin Xu, Luyao Jiang, Tingting Guo, Changchao Huan
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
glycyrrhizin
PEDV infection
proinflammatory cytokine
HMGB1
TLR4
MAPK p38
Online Access:https://www.mdpi.com/1422-0067/21/8/2961

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