Collective cell mechanics of epithelial shells with organoid-like morphologies

Collective cell mechanics of epithelial shells with organoid-like morphologies

The physical origins of man-made tissue morphologies with organ-like microscopic anatomy and functionality remain poorly understood. Here, authors propose a mechanistic theory of these structures, employing a 3D vertex model to reproduce the characteristic morphologies such as branched shapes.

Bibliographic Details
Main Authors: Jan Rozman, Matej Krajnc, Primož Ziherl
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17535-4
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spelling doaj-89f72efd68ce42ac98995d45803175512021-08-01T11:39:48ZengNature Publishing GroupNature Communications2041-17232020-07-011111910.1038/s41467-020-17535-4Collective cell mechanics of epithelial shells with organoid-like morphologiesJan Rozman0Matej Krajnc1Primož Ziherl2Jožef Stefan InstituteJožef Stefan InstituteJožef Stefan InstituteThe physical origins of man-made tissue morphologies with organ-like microscopic anatomy and functionality remain poorly understood. Here, authors propose a mechanistic theory of these structures, employing a 3D vertex model to reproduce the characteristic morphologies such as branched shapes.https://doi.org/10.1038/s41467-020-17535-4
collection DOAJ
language English
format Article
sources DOAJ
author Jan Rozman
Matej Krajnc
Primož Ziherl
spellingShingle Jan Rozman
Matej Krajnc
Primož Ziherl
Collective cell mechanics of epithelial shells with organoid-like morphologies
Nature Communications
author_facet Jan Rozman
Matej Krajnc
Primož Ziherl
author_sort Jan Rozman
title Collective cell mechanics of epithelial shells with organoid-like morphologies
title_short Collective cell mechanics of epithelial shells with organoid-like morphologies
title_full Collective cell mechanics of epithelial shells with organoid-like morphologies
title_fullStr Collective cell mechanics of epithelial shells with organoid-like morphologies
title_full_unstemmed Collective cell mechanics of epithelial shells with organoid-like morphologies
title_sort collective cell mechanics of epithelial shells with organoid-like morphologies
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-07-01
description The physical origins of man-made tissue morphologies with organ-like microscopic anatomy and functionality remain poorly understood. Here, authors propose a mechanistic theory of these structures, employing a 3D vertex model to reproduce the characteristic morphologies such as branched shapes.
url https://doi.org/10.1038/s41467-020-17535-4
work_keys_str_mv AT janrozman collectivecellmechanicsofepithelialshellswithorganoidlikemorphologies
AT matejkrajnc collectivecellmechanicsofepithelialshellswithorganoidlikemorphologies
AT primozziherl collectivecellmechanicsofepithelialshellswithorganoidlikemorphologies
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