A cyto-histo pathological correlation of bladder tumors in relation to smoking as a risk factor

• Main Authors: Tanushree Satpathy, Binapani Satpathy, Sukumar Chakraborty, Prasanna Kumar Satpathy, Payala Vijayalakshmi
• Format: Article
• Language: English
• Published: Deccan College of Medical Sciences 2018-07-01
• Series: Journal of Medical and Allied Sciences
• Subjects: Bladder tumor; CECT; Cytodiagnosis; Fluorescence in-situ hybridization; Histopathology; Immune histochemistry; Smoking
• Online Access: http://www.ejmanager.com/fulltextpdf.php?mno=293731

Urinary bladder serve as an excretory dustbin, is exposed to all toxic and non toxic substances excreted by the body, thus it is a host to many metaplastic and neoplastic conditions apart from inflammatory changes. Urinary cytodiagnosis and biopsy studies are sufficient for confirmation in most cases. In this study also an attempt has been made to correlate smoking as a high risk factor. To correlate cytology and histology of different bladder tumors with smoking as a predisposing factor. This study was conducted on 74 patients who were admitted to the department of urology, Hi-Tech Medical College, Bhubaneswar between June 2012 and October 2014. Routine urinary cytology was done and stained by both diff quick and papanicoloke stain and biopsy specimen were stained by hematoxylin and eosin stains. By standard questionnaire the history of smoking was documented with consent from the patients who were included in the study. Out of 74 cases, 17 cases did not turn up for follow up. Samples were inadequate in 5 cases. 52 cases were analyzed in the study. Strong correlation between cytodiagnosis and histology was observed with over all sensitivity 92.5% and specificity 80.0%. Out of 52 cases 21 were having history of smoking upto 10 cigarettes a day for a period of more than 20 years and 17 of them had high grade urothetial carcinoma 40.3% and 31 non smokers had 21.1% risk of developing bladder tumors. The present study concluded that urinary cytodiagnosis is well correlated with histopathology of bladder tumors. This can be performed in centres where molecular marker study is not available. This is fairly cheap and accurate for early diagnosis and treatment. History of smoking habit is equally important to correlate with bladder tumors as a risk factor. [J Med Allied Sci 2018; 8(2.000): 73-77]