Acceptability of thioamides II. Prothionamide

• Main Author: Gupta D
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 1977-01-01
• Series: Journal of Postgraduate Medicine
• Online Access: http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1977;volume=23;issue=4;spage=181;epage=185;aulast=Gupta

One hundred and fourteen patients with chronic advanced pulmonary tuberculosis were studied for 6 months to assess the acceptability of prothionamide at different dosage schedules and frequencies of intake of the drug. Gastrointestinal disturbances were most frequently encountered in patients of all the groups. Mild to severe toxic symptoms were recorded in 34.3 per cent, 44.7 per cent and 80 per cent patients receiving the drug in a daily dose of 500 mg, 750 mg and 1 gm respectively in groups A, B and C. At a dose of 500 mg per day, the incidence of toxicity was identical in the two sexes but beyond this dose it was slightly higher in females than in males. Age, chronicity o f illness and extent o f diseases did not have any influence on prothionamide acceptability. Toxic symptoms developed earlier in patients receiving higher doses of the drug. Prothionamide in a dose of 500 mg per day was very well tolerated by 65.7 per cent of patients and a considerable number of them tolerated a dose of 750 mg per day.