Impaired plasticity of intrinsic excitability in the dentate gyrus alters spike transfer in a mouse model of Alzheimer's disease

Impaired plasticity of intrinsic excitability in the dentate gyrus alters spike transfer in a mouse model of Alzheimer's disease

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by cognitive decline related to deficits in synaptic transmission and plasticity. We report in APP/PS1 mice, a double transgenic mouse model of AD, that females displayed an early burden of Aβ plaques load in the...

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Bibliographic Details
Main Authors: Nan Jiang, Dario Cupolillo, Noelle Grosjean, Emeline Muller, Séverine Deforges, Christophe Mulle, Thierry Amédée
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Dentate gyrus
Intrinsic excitability
Perforant pathway
Synaptic plasticity
Hippocampus
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121000942

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http://www.sciencedirect.com/science/article/pii/S0969996121000942

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