The Effect of Melatonin on Periodontitis
Background: Periodontitis is a chronic disease with a complex etiology that includes bacterial colonization, excessive inflammation, and oxidative stress. The hormone melatonin has antioxidant properties and might contribute to alleviating chronic conditions by reducing oxidative stress. The aim of...
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doaj-89c2b001913a4914bceed1a56039ab4c2021-02-28T00:03:59ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01222390239010.3390/ijms22052390The Effect of Melatonin on PeriodontitisBarbora Konečná0Paulína Chobodová1Jakub Janko2Lenka Baňasová3Janka Bábíčková4Peter Celec5Ľubomíra Tóthová6Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 811 08 Bratislava, SlovakiaInstitute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 811 08 Bratislava, SlovakiaInstitute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 811 08 Bratislava, SlovakiaDepartment of Stomatology and Maxillofacial Surgery, Comenius University, 812 50 Bratislava, SlovakiaInstitute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 811 08 Bratislava, SlovakiaInstitute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 811 08 Bratislava, SlovakiaInstitute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 811 08 Bratislava, SlovakiaBackground: Periodontitis is a chronic disease with a complex etiology that includes bacterial colonization, excessive inflammation, and oxidative stress. The hormone melatonin has antioxidant properties and might contribute to alleviating chronic conditions by reducing oxidative stress. The aim of this study was to analyze the effect of exogenous melatonin on periodontitis in an animal model of the disease as well as in patients with periodontitis. Methods: In rats with ligature-induced periodontitis, melatonin was administered in drinking water for two weeks. In the human study, patients with treatment-resistant periodontitis were asked to rinse their mouths with a solution containing melatonin or placebo every evening for two weeks. Periodontal status as well as salivary markers of oxidative stress were assessed at the end of the study. Results: Neither radiography nor μCT revealed any significant effects of melatonin on alveolar bone loss. Gum recession was the only improved macroscopic measure in rats (<i>p</i> < 0.05). Analysis of salivary markers of oxidative stress revealed no effects of treatment in rats or humans despite clearly elevated melatonin concentrations in melatonin treated groups. Conclusion: Our results do not support the use of melatonin for the treatment of periodontitis. However, the negative outcome is limited by the short duration of the study and the chosen route of application as well as the dose of melatonin.https://www.mdpi.com/1422-0067/22/5/2390periodontal diseaseantioxidant treatmentmicro-computed tomography |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Barbora Konečná Paulína Chobodová Jakub Janko Lenka Baňasová Janka Bábíčková Peter Celec Ľubomíra Tóthová |
spellingShingle |
Barbora Konečná Paulína Chobodová Jakub Janko Lenka Baňasová Janka Bábíčková Peter Celec Ľubomíra Tóthová The Effect of Melatonin on Periodontitis International Journal of Molecular Sciences periodontal disease antioxidant treatment micro-computed tomography |
author_facet |
Barbora Konečná Paulína Chobodová Jakub Janko Lenka Baňasová Janka Bábíčková Peter Celec Ľubomíra Tóthová |
author_sort |
Barbora Konečná |
title |
The Effect of Melatonin on Periodontitis |
title_short |
The Effect of Melatonin on Periodontitis |
title_full |
The Effect of Melatonin on Periodontitis |
title_fullStr |
The Effect of Melatonin on Periodontitis |
title_full_unstemmed |
The Effect of Melatonin on Periodontitis |
title_sort |
effect of melatonin on periodontitis |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-02-01 |
description |
Background: Periodontitis is a chronic disease with a complex etiology that includes bacterial colonization, excessive inflammation, and oxidative stress. The hormone melatonin has antioxidant properties and might contribute to alleviating chronic conditions by reducing oxidative stress. The aim of this study was to analyze the effect of exogenous melatonin on periodontitis in an animal model of the disease as well as in patients with periodontitis. Methods: In rats with ligature-induced periodontitis, melatonin was administered in drinking water for two weeks. In the human study, patients with treatment-resistant periodontitis were asked to rinse their mouths with a solution containing melatonin or placebo every evening for two weeks. Periodontal status as well as salivary markers of oxidative stress were assessed at the end of the study. Results: Neither radiography nor μCT revealed any significant effects of melatonin on alveolar bone loss. Gum recession was the only improved macroscopic measure in rats (<i>p</i> < 0.05). Analysis of salivary markers of oxidative stress revealed no effects of treatment in rats or humans despite clearly elevated melatonin concentrations in melatonin treated groups. Conclusion: Our results do not support the use of melatonin for the treatment of periodontitis. However, the negative outcome is limited by the short duration of the study and the chosen route of application as well as the dose of melatonin. |
topic |
periodontal disease antioxidant treatment micro-computed tomography |
url |
https://www.mdpi.com/1422-0067/22/5/2390 |
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