Muscarinic inhibition of salivary glands with glycopyrronium bromide does not reduce the uptake of PSMA-ligands or radioiodine

Muscarinic inhibition of salivary glands with glycopyrronium bromide does not reduce the uptake of PSMA-ligands or radioiodine

Abstract Rationale Salivary glands are highly perfused and express the prostate-specific membrane antigen (PSMA) receptor as well as the sodium—iodide symporter. As a consequence, treatment with 177Lu/225Ac-PSMA for prostate cancer or 131I for thyroid cancer leads to a high radiation dose in the sal...

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Main Authors: V. Mohan, N. M. Bruin, M. E. T. Tesselaar, J. P. de Boer, E. Vegt, J. J. M. A. Hendrikx, A. Al-Mamgani, J. B. van de Kamer, J.-J. Sonke, W. V. Vogel
Format: Article
Language:English
Published: SpringerOpen 2021-03-01
Series:EJNMMI Research
Subjects:
Salivary glands
Toxicity
PSMA
Iodine
Radionuclide therapy
Online Access:https://doi.org/10.1186/s13550-021-00770-1

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