Selective Cytotoxicity of Piperine Over Multidrug Resistance Leukemic Cells

Selective Cytotoxicity of Piperine Over Multidrug Resistance Leukemic Cells

Multidrug resistance (MDR) is the main challenge in the treatment of chronic myeloid leukemia (CML), and P-glycoprotein (P-gp) overexpression is an important mechanism involved in this resistance process. However, some compounds can selectively affect MDR cells, inducing collateral sensitivity (CS),...

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Bibliographic Details
Main Authors: Julia Quarti, Daianne N. M. Torres, Erika Ferreira, Raphael S. Vidal, Fabiana Casanova, Luciana B. Chiarini, Eliane Fialho, Vivian M. Rumjanek
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Molecules
Subjects:
chronic myeloid leukemia
multidrug resistance
piperine
collateral sensitivity
PARP-1
Online Access:https://www.mdpi.com/1420-3049/26/4/934

Internet

https://www.mdpi.com/1420-3049/26/4/934

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