Bortezomib modulates CHIT1 and YKL40 in monocyte-derived osteoclast and in myeloma cells

Bortezomib modulates CHIT1 and YKL40 in monocyte-derived osteoclast and in myeloma cells

Osteolytic bone disease is a common manifestation of multiple myeloma (MM) that leads to progressive skeleton destruction and is the most severe cause of morbidity in MM patients.It results from increased osteolytic activity and decrease osteoblastic function. Activation of mammalian chitinases CHIT...

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Bibliographic Details
Main Authors: Tibullo eDaniele, Michelino eDi Rosa, Cesarina eGiallongo, Piera eLa Cava, Nunziatina L Parrinello, Alessandra eRomano, Concetta eConticello, Maria V. Brundo, Salvatore eSaccone, Lucia eMalaguarnera, Francesco eDi Raimondo
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Pharmacology
Subjects:
Multiple Myeloma
Myeloma
Bortezomib
YKL-40
CHIT1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00226/full

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