ASSESSMENT OF CYTOTOXIC EFFECT OF LOW-DIMENSIONAL ALUMINUM OXIDE STRUCTURES ON TUMOR CELLS

• Main Authors: M. S. Korovin, O. V. Bakina, A. N. Fomenko, M. I. Lerner
• Format: Article
• Language: Russian
• Published: Tomsk National Research Medical Center of the Russian Academy of Sciences 2016-12-01
• Series: Sibirskij Onkologičeskij Žurnal
• Subjects: aluminum oxide; nanostructures; agglomerates of nanosheets; nanoplates; cone-shaped nanoaggregates; mtt assay; tumor cells; toxicity
• Online Access: https://www.siboncoj.ru/jour/article/view/443
• ISSN: 1814-4861; 2312-3168

Nano-dimensional materials have recently attracted much attention of researchers with respect of their potential role in medicine. Physical mechanisms of interaction of nanostructures with tumor cells will help to develop new approaches to treatment of cancer. Recent studies have shown that the physicochemical properties of nanostructures, such as shape and size, are the important factors of their biological activity and toxicity. the purpose of the study was to determine the role of the shape of aluminum oxide nanostructures in their toxic effects on tumor cells. material and methods. Based on aluminum oxide phases, positively charged lowdimensional structures having different shapes (agglomerates of nanosheets, nameplates, and cone-shaped nanoaggregates) were synthesized with the help of aluminum nanoparticles. The resulting particles were characterized by transmission electron microscopy and Xray diffraction. The toxicity effect of low-dimensional aluminum oxide structures was assessed by MTT assay using A549, HeLa, MDA and PyMT cell lines. results. Agglomerates of nanosheets were shown to have the most pronounced toxic effect on the examined cell lines, while nanoplates and cone-shaped nanoaggregates were non-toxic. Conclusion. The toxic effect of agglomerates of