COMPOSITE POLYMER MATRICES FOR TISSUE ENGINEERING AND TRANSPLANTOLOGY

• Main Authors: Dobrovolskaya Irina, Ivankova Elena, Popryadukhin Pavel, Yudin Vladimir
• Format: Article
• Language: English
• Published: Peter the Great St.Petersburg Polytechnic University 2019-09-01
• Series: St. Petersburg Polytechnical University Journal: Physics and Mathematics
• Subjects: chitosan; chitin nanofibrilla; tissue engineering; composite nanofiber; composite sponge
• Online Access: https://physmath.spbstu.ru/article/2019.45.09/

The article describes modern methods for producing one-, two-, and three-dimensional composite matrices for tissue engineering based on resorbable and non-resorbable polymers. Coagulation method for producing composite fibers based on chitosan and chitin nanofibrils, electrospinning method for composite nanofibers, lyophilization of chitosan solutions and their mixtures with nanoparticles to obtain three-dimensional porous matrices with increased stability of mechanical characteristics in aqueous media. The results of the study of the adhesion and kinetics of proliferation of stem and somatic cells of humans and animals on the developed matrices are presented. In vivo experiments have shown that materials in the form of fibers, films, tubular samples, and sponges can be used as implants for blood vessels, effective wound dressings. The article contains the results of the study of the kinetics of resorption of the studied materials in a living organism.