Negative Immunomodulatory Effects of Type 2 Porcine Reproductive and Respiratory Syndrome Virus-Induced Interleukin-1 Receptor Antagonist on Porcine Innate and Adaptive Immune Functions

Negative Immunomodulatory Effects of Type 2 Porcine Reproductive and Respiratory Syndrome Virus-Induced Interleukin-1 Receptor Antagonist on Porcine Innate and Adaptive Immune Functions

Impaired innate and adaptive immune responses are evidenced throughout the course of PRRSV infection. We previously reported that interleukin-1 receptor antagonist (IL-1Ra) was involved in PRRSV-induced immunosuppression during an early phase of infection. However, the exact mechanism associated wit...

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Bibliographic Details
Main Authors: Teerawut Nedumpun, Navapon Techakriengkrai, Roongroje Thanawongnuwech, Sanipa Suradhat
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
type 2 PRRSV
pig
immunomodulatory effect
IL-1Ra
interleukin-1 receptor antagonist
innate and adaptive immune response
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00579/full

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