The Representative Porcine Model for Human Cardiovascular Disease

The Representative Porcine Model for Human Cardiovascular Disease

To improve human health, scientific discoveries must be translated into practical applications. Inherent in the development of these technologies is the role of preclinical testing using animal models. Although significant insight into the molecular and cellular basis has come from small animal mode...

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Main Authors: Yoriyasu Suzuki, Alan C. Yeung, Fumiaki Ikeno
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Journal of Biomedicine and Biotechnology
Online Access:http://dx.doi.org/10.1155/2011/195483
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spelling doaj-89aa5104573d463d91c7f80a440933e92020-11-24T21:50:57ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512011-01-01201110.1155/2011/195483195483The Representative Porcine Model for Human Cardiovascular DiseaseYoriyasu Suzuki0Alan C. Yeung1Fumiaki Ikeno2Division of Cardiovascular Medicine, Nagoya Heart Center, 461-0045 Aichi, JapanDivision of Cardiovascular Medicine, School of Medicine, Stanford University, 300 Pasteur Drive, Falk CVRB007, Stanford, CA94305, USADivision of Cardiovascular Medicine, School of Medicine, Stanford University, 300 Pasteur Drive, Falk CVRB007, Stanford, CA94305, USATo improve human health, scientific discoveries must be translated into practical applications. Inherent in the development of these technologies is the role of preclinical testing using animal models. Although significant insight into the molecular and cellular basis has come from small animal models, significant differences exist with regard to cardiovascular characteristics between these models and humans. Therefore, large animal models are essential to develop the discoveries from murine models into clinical therapies and interventions. This paper will provide an overview of the more frequently used large animal models, especially porcine models for preclinical studies.http://dx.doi.org/10.1155/2011/195483
collection DOAJ
language English
format Article
sources DOAJ
author Yoriyasu Suzuki
Alan C. Yeung
Fumiaki Ikeno
spellingShingle Yoriyasu Suzuki
Alan C. Yeung
Fumiaki Ikeno
The Representative Porcine Model for Human Cardiovascular Disease
Journal of Biomedicine and Biotechnology
author_facet Yoriyasu Suzuki
Alan C. Yeung
Fumiaki Ikeno
author_sort Yoriyasu Suzuki
title The Representative Porcine Model for Human Cardiovascular Disease
title_short The Representative Porcine Model for Human Cardiovascular Disease
title_full The Representative Porcine Model for Human Cardiovascular Disease
title_fullStr The Representative Porcine Model for Human Cardiovascular Disease
title_full_unstemmed The Representative Porcine Model for Human Cardiovascular Disease
title_sort representative porcine model for human cardiovascular disease
publisher Hindawi Limited
series Journal of Biomedicine and Biotechnology
issn 1110-7243
1110-7251
publishDate 2011-01-01
description To improve human health, scientific discoveries must be translated into practical applications. Inherent in the development of these technologies is the role of preclinical testing using animal models. Although significant insight into the molecular and cellular basis has come from small animal models, significant differences exist with regard to cardiovascular characteristics between these models and humans. Therefore, large animal models are essential to develop the discoveries from murine models into clinical therapies and interventions. This paper will provide an overview of the more frequently used large animal models, especially porcine models for preclinical studies.
url http://dx.doi.org/10.1155/2011/195483
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AT alancyeung therepresentativeporcinemodelforhumancardiovasculardisease
AT fumiakiikeno therepresentativeporcinemodelforhumancardiovasculardisease
AT yoriyasusuzuki representativeporcinemodelforhumancardiovasculardisease
AT alancyeung representativeporcinemodelforhumancardiovasculardisease
AT fumiakiikeno representativeporcinemodelforhumancardiovasculardisease
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