Donor variability may mask dimethyl fumarate’s effects on nuclear factor E2-related factor 2 in human peripheral blood mononuclear cells

Donor variability may mask dimethyl fumarate’s effects on nuclear factor E2-related factor 2 in human peripheral blood mononuclear cells

Abstract Objective Dimethyl fumarate (DMF) is an anti-inflammatory and antioxidant drug used to treat multiple sclerosis, but its mechanism(s) of action are not fully understood. In central nervous system (CNS) cells, DMF activates nuclear factor E2-related factor 2 (Nrf2), perhaps ameliorating oxid...

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Bibliographic Details
Main Authors: Sarah E. Fiedler, Amelia R. Kerns, Catherine Tsang, Haley N. Love, Sonemany Salinthone
Format: Article
Language:English
Published: BMC 2017-11-01
Series:BMC Research Notes
Subjects:
Dimethyl fumarate
Nrf2
Peripheral blood mononuclear cell
HO-1
Cyclic AMP
Online Access:http://link.springer.com/article/10.1186/s13104-017-2862-8

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http://link.springer.com/article/10.1186/s13104-017-2862-8

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