Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex

Interorganelle membrane contact sites between the endoplasmic reticulum and mitochondria can be mediated with the ER-mitochondria encounter structure (ERMES) complex, though precise regulation is unclear. Here, the authors report that the number of ERMES foci is regulated by the previously uncharact...

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Main Authors:	Faiz Rasul, Fan Zheng, Fenfen Dong, Jiajia He, Ling Liu, Wenyue Liu, Javairia Yousuf Cheema, Wenfan Wei, Chuanhai Fu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-20866-x

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spelling	doaj-89a4da49fba64046b10a14698cbfdd0f2021-01-24T12:12:25ZengNature Publishing GroupNature Communications2041-17232021-01-0112111410.1038/s41467-020-20866-xEmr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complexFaiz Rasul0Fan Zheng1Fenfen Dong2Jiajia He3Ling Liu4Wenyue Liu5Javairia Yousuf Cheema6Wenfan Wei7Chuanhai Fu8Ministry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMinistry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMinistry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMinistry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMinistry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMinistry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMinistry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMinistry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaMinistry of Education Key Laboratory for Membrane-less Organelles & Cellular Dynamics, CAS Center for Excellence in Molecular Cell Sciences, Hefei National Laboratory for Physical Sciences at the Microscale, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of ChinaInterorganelle membrane contact sites between the endoplasmic reticulum and mitochondria can be mediated with the ER-mitochondria encounter structure (ERMES) complex, though precise regulation is unclear. Here, the authors report that the number of ERMES foci is regulated by the previously uncharacterized mitochondrial membrane protein Emr1.https://doi.org/10.1038/s41467-020-20866-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Faiz Rasul Fan Zheng Fenfen Dong Jiajia He Ling Liu Wenyue Liu Javairia Yousuf Cheema Wenfan Wei Chuanhai Fu
spellingShingle	Faiz Rasul Fan Zheng Fenfen Dong Jiajia He Ling Liu Wenyue Liu Javairia Yousuf Cheema Wenfan Wei Chuanhai Fu Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex Nature Communications
author_facet	Faiz Rasul Fan Zheng Fenfen Dong Jiajia He Ling Liu Wenyue Liu Javairia Yousuf Cheema Wenfan Wei Chuanhai Fu
author_sort	Faiz Rasul
title	Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex
title_short	Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex
title_full	Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex
title_fullStr	Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex
title_full_unstemmed	Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex
title_sort	emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-01-01
description	Interorganelle membrane contact sites between the endoplasmic reticulum and mitochondria can be mediated with the ER-mitochondria encounter structure (ERMES) complex, though precise regulation is unclear. Here, the authors report that the number of ERMES foci is regulated by the previously uncharacterized mitochondrial membrane protein Emr1.
url	https://doi.org/10.1038/s41467-020-20866-x
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Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex

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