Genetic Tracing of Clonal Expansion and Progression of Pancreatic Ductal Adenocarcinoma: A Case Report and Multi-Region Sequencing Analysis

Genetic Tracing of Clonal Expansion and Progression of Pancreatic Ductal Adenocarcinoma: A Case Report and Multi-Region Sequencing Analysis

Pancreatobiliary tumors frequently contain multiple malignant and precancerous lesions; however, the origin of the driver mutations and the mechanisms that underlie the generation of distinct clones within an organ field remain unclear. Herein, we describe a 76-year-old male suffering from moderatel...

Full description

Bibliographic Details
Main Authors: Shion Tachibana, Yusuke Mizukami, Yusuke Ono, Yuya Sugiyama, Tetsuhiro Okada, Arisa Kitazaki, Junpei Sasajima, Motoya Tominaga, Jun Sakamoto, Keisuke Kimura, Yuko Omori, Toru Furukawa, Taichi Kimura, Shinya Tanaka, Kazuo Nagashima, Hidenori Karasaki, Tomoyuki Ohta, Toshikatsu Okumura
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Oncology
Subjects:
pancreatic cancer
premalignant field defect
clonal evolution
multi-region sequencing
KRAS
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00728/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00728/full

Similar Items