Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors

Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors

Chronic itch affects about 10% of the general population, however current treatments are largely ineffective. Here, the authors show that targeting of inhibitory α2 and α3GABAA receptors reduces itch in mice and in a canine model, suggesting this a potentially useful therapeutic approach.

Bibliographic Details
Main Authors: William T. Ralvenius, Elena Neumann, Martina Pagani, Mario A. Acuña, Hendrik Wildner, Dietmar Benke, Nina Fischer, Ana Rostaher, Simon Schwager, Michael Detmar, Katrin Frauenknecht, Adriano Aguzzi, Jed Lee Hubbs, Uwe Rudolph, Claude Favrot, Hanns Ulrich Zeilhofer
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05709-0

Internet

https://doi.org/10.1038/s41467-018-05709-0

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