CDX2 expression in the hematopoietic lineage promotes leukemogenesis via TGFβ inhibition

CDX2 expression in the hematopoietic lineage promotes leukemogenesis via TGFβ inhibition

The intestine‐specific caudal‐related homeobox gene‐2 (CDX2) homeobox gene, while being a tumor suppressor in the gut, is ectopically expressed in a large proportion of acute leukemia and is associated with poor prognosis. Here, we report that turning on human CDX2 expression in the hematopoietic li...

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Bibliographic Details
Main Authors: Ava Galland, Victor Gourain, Karima Habbas, Yonca Güler, Elisabeth Martin, Claudine Ebel, Manuela Tavian, Laurent Vallat, Marie‐Pierre Chenard, Laurent Mauvieux, Jean‐Noël Freund, Isabelle Duluc, Claire Domon‐Dell
Format: Article
Language:English
Published: Wiley 2021-09-01
Series:Molecular Oncology
Subjects:
acute monoblastic leukemia
BAMBI
ectopic expression
oncogene
tumor suppressor
Online Access:https://doi.org/10.1002/1878-0261.12982

Internet

https://doi.org/10.1002/1878-0261.12982

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