Type I interferon response-related microglial Mef2c deregulation at the onset of Alzheimer's pathology in 5×FAD mice

Type I interferon response-related microglial Mef2c deregulation at the onset of Alzheimer's pathology in 5×FAD mice

Alzheimer's disease (AD) is a chronic neurodegenerative disorder with multifactorial etiology. The role of microglia in the pathogenesis of AD has been increasingly recognized in recent years; however, the detailed mechanisms shaping microglial phenotypes in AD-relevant pathological settings re...

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Bibliographic Details
Main Authors: Feng Xue, Jing Tian, Chunxiao Yu, Heng Du, Lan Guo
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Neurobiology of Disease
Subjects:
Type I interferon
Myocyte-specific enhancer factor 2C
Microglia
Amyloid beta
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121000218

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