PBX3 in Cancer
PBX3 is a homeodomain-containing transcription factor of the pre-B cell leukemia (PBX) family, members of which have extensive roles in early development and some adult processes. A number of features distinguish PBX3 from other PBX proteins, including the ability to form specific and stable interac...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/2/431 |
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doaj-897003241db24ad2a15ac135f1fcf5912020-11-25T03:32:00ZengMDPI AGCancers2072-66942020-02-0112243110.3390/cancers12020431cancers12020431PBX3 in CancerRichard Morgan0Hardev S Pandha1Institute of Cancer Therapeutics, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UKFaculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UKPBX3 is a homeodomain-containing transcription factor of the pre-B cell leukemia (PBX) family, members of which have extensive roles in early development and some adult processes. A number of features distinguish PBX3 from other PBX proteins, including the ability to form specific and stable interactions with DNA in the absence of cofactors. PBX3 has frequently been reported as having a role in the development and maintenance of a malignant phenotype, and high levels of PBX3 tumor expression have been linked to shorter overall survival in cancer. In this review we consider the similarities and differences in the function of PBX3 in different cancer types and draw together the core signaling pathways involved to help provide a better insight into its potential as a therapeutic target.https://www.mdpi.com/2072-6694/12/2/431pbx3pbxhoxmicrornaacute myeloid leukemiagastric cancercolorectal cancerliver cancer |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Richard Morgan Hardev S Pandha |
| spellingShingle |
Richard Morgan Hardev S Pandha PBX3 in Cancer Cancers pbx3 pbx hox microrna acute myeloid leukemia gastric cancer colorectal cancer liver cancer |
| author_facet |
Richard Morgan Hardev S Pandha |
| author_sort |
Richard Morgan |
| title |
PBX3 in Cancer |
| title_short |
PBX3 in Cancer |
| title_full |
PBX3 in Cancer |
| title_fullStr |
PBX3 in Cancer |
| title_full_unstemmed |
PBX3 in Cancer |
| title_sort |
pbx3 in cancer |
| publisher |
MDPI AG |
| series |
Cancers |
| issn |
2072-6694 |
| publishDate |
2020-02-01 |
| description |
PBX3 is a homeodomain-containing transcription factor of the pre-B cell leukemia (PBX) family, members of which have extensive roles in early development and some adult processes. A number of features distinguish PBX3 from other PBX proteins, including the ability to form specific and stable interactions with DNA in the absence of cofactors. PBX3 has frequently been reported as having a role in the development and maintenance of a malignant phenotype, and high levels of PBX3 tumor expression have been linked to shorter overall survival in cancer. In this review we consider the similarities and differences in the function of PBX3 in different cancer types and draw together the core signaling pathways involved to help provide a better insight into its potential as a therapeutic target. |
| topic |
pbx3 pbx hox microrna acute myeloid leukemia gastric cancer colorectal cancer liver cancer |
| url |
https://www.mdpi.com/2072-6694/12/2/431 |
| work_keys_str_mv |
AT richardmorgan pbx3incancer AT hardevspandha pbx3incancer |
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