DCEBIO facilitates myogenic differentiation via intermediate conductance Ca2+ activated K+ channel activation in C2C12 myoblasts

DCEBIO facilitates myogenic differentiation via intermediate conductance Ca2+ activated K+ channel activation in C2C12 myoblasts

Membrane hyperpolarization is suggested to be a trigger for skeletal muscle differentiation. We investigated whether DCEBIO, an opener of the small/intermediate conductance Ca2+ activated K+ (SKCa/IKCa) channels, increase myogenic differentiation in C2C12 skeletal myoblasts. DCEBIO significantly inc...

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Bibliographic Details
Main Authors: Shoko Tanaka, Yuko Ono, Kazuho Sakamoto
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Journal of Pharmacological Sciences
Subjects:
Ca2+ activated K+ channel
Myogenic differentiation
Skeletal muscle
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861317300208

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