Evaluation of antidiabetic activity of aqueous extract of <em>Origanum floribundum</em> Munby leaves in alloxan induced diabetic rats wistar

• Main Authors: M'hamed Nasri, Mohamed Zaouani, Noura Mimoune, Fatma Amira Hani, Mohamed Mahdid, Mohamed Toumi
• Format: Article
• Language: English
• Published: PAGEPress Publications 2021-01-01
• Series: Journal of Biological Research
• Subjects: Aqueous extract; diabetes; rats; Origanum floribundum; acute toxicity
• Online Access: https://www.pagepressjournals.org/index.php/jbr/article/view/9141

The present study aimed to evaluate the phytochemicals and the antidiabetic properties of Origanum floribundum aqueous extract. Phytochemical screening was conducted by using various standard procedures. Acute toxicity of the extract was determined by OECD guidelines 423. The antidiabetic activity of the plant was determined by alloxan-induced diabetes in Wistar albino rats. Data obtained showed the detection of various secondary metabolites such as alkaloids, flavonoids, saponins, terpenoids in the extract. No mortality was observed during acute toxicity studies up to the dose of 2000 mg/kg. The aqueous extract presented the ability of reducing blood glucose levels. These findings indicated that Origanum floribundum aqueous extract had various phytopharmacological activities and thus it would be useful to isolate and characterize the compounds responsible for these bioactivities in the future.