Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing

Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing

CRISPR-based base editors allow for single nucleotide genome editing in a range of organisms. Here the authors demonstrate the in vivo generation of mouse models carrying clinically relevant mutations using C→T and A→G editors.

Bibliographic Details
Main Authors: Zhen Liu, Zongyang Lu, Guang Yang, Shisheng Huang, Guanglei Li, Songjie Feng, Yajing Liu, Jianan Li, Wenxia Yu, Yu Zhang, Jia Chen, Qiang Sun, Xingxu Huang
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04768-7

Internet

https://doi.org/10.1038/s41467-018-04768-7

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