Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing

CRISPR-based base editors allow for single nucleotide genome editing in a range of organisms. Here the authors demonstrate the in vivo generation of mouse models carrying clinically relevant mutations using C→T and A→G editors.

Bibliographic Details
Main Authors:	Zhen Liu, Zongyang Lu, Guang Yang, Shisheng Huang, Guanglei Li, Songjie Feng, Yajing Liu, Jianan Li, Wenxia Yu, Yu Zhang, Jia Chen, Qiang Sun, Xingxu Huang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-04768-7

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spelling	doaj-8958562bd535472e9a0b1a20d93534292021-05-11T10:18:09ZengNature Publishing GroupNature Communications2041-17232018-06-01911810.1038/s41467-018-04768-7Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editingZhen Liu0Zongyang Lu1Guang Yang2Shisheng Huang3Guanglei Li4Songjie Feng5Yajing Liu6Jianan Li7Wenxia Yu8Yu Zhang9Jia Chen10Qiang Sun11Xingxu Huang12Institute of Neuroscience, Chinese Academy of Sciences (CAS) Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, CASSchool of Life Science and Technology, ShanghaiTech UniversitySchool of Life Science and Technology, ShanghaiTech UniversitySchool of Life Science and Technology, ShanghaiTech UniversitySchool of Life Science and Technology, ShanghaiTech UniversityInstitute of Neuroscience, Chinese Academy of Sciences (CAS) Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, CASSchool of Life Science and Technology, ShanghaiTech UniversitySchool of Life Science and Technology, ShanghaiTech UniversitySchool of Life Science and Technology, ShanghaiTech UniversitySchool of Life Science and Technology, ShanghaiTech UniversitySchool of Life Science and Technology, ShanghaiTech UniversityInstitute of Neuroscience, Chinese Academy of Sciences (CAS) Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, CASSchool of Life Science and Technology, ShanghaiTech UniversityCRISPR-based base editors allow for single nucleotide genome editing in a range of organisms. Here the authors demonstrate the in vivo generation of mouse models carrying clinically relevant mutations using C→T and A→G editors.https://doi.org/10.1038/s41467-018-04768-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zhen Liu Zongyang Lu Guang Yang Shisheng Huang Guanglei Li Songjie Feng Yajing Liu Jianan Li Wenxia Yu Yu Zhang Jia Chen Qiang Sun Xingxu Huang
spellingShingle	Zhen Liu Zongyang Lu Guang Yang Shisheng Huang Guanglei Li Songjie Feng Yajing Liu Jianan Li Wenxia Yu Yu Zhang Jia Chen Qiang Sun Xingxu Huang Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing Nature Communications
author_facet	Zhen Liu Zongyang Lu Guang Yang Shisheng Huang Guanglei Li Songjie Feng Yajing Liu Jianan Li Wenxia Yu Yu Zhang Jia Chen Qiang Sun Xingxu Huang
author_sort	Zhen Liu
title	Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing
title_short	Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing
title_full	Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing
title_fullStr	Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing
title_full_unstemmed	Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing
title_sort	efficient generation of mouse models of human diseases via abe- and be-mediated base editing
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-06-01
description	CRISPR-based base editors allow for single nucleotide genome editing in a range of organisms. Here the authors demonstrate the in vivo generation of mouse models carrying clinically relevant mutations using C→T and A→G editors.
url	https://doi.org/10.1038/s41467-018-04768-7
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Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing

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