Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing
CRISPR-based base editors allow for single nucleotide genome editing in a range of organisms. Here the authors demonstrate the in vivo generation of mouse models carrying clinically relevant mutations using C→T and A→G editors.
Bibliographic Details
| Main Authors: |
Zhen Liu,
Zongyang Lu,
Guang Yang,
Shisheng Huang,
Guanglei Li,
Songjie Feng,
Yajing Liu,
Jianan Li,
Wenxia Yu,
Yu Zhang,
Jia Chen,
Qiang Sun,
Xingxu Huang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2018-06-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-04768-7
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