Exploring the potential of flubendazole in filariasis control: evaluation of the systemic exposure for different pharmaceutical preparations.
The goal of elimination of the human filariases would benefit greatly from the use of a macrofilaricidal agent. In vivo trials in humans and many experimental animal models suggest that flubendazole (FLBZ) is a highly efficacious macrofilaricide. However, since serious injection site reactions were...
Main Authors: | Laura Ceballos, Charles Mackenzie, Timothy Geary, Luis Alvarez, Carlos Lanusse |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS Neglected Tropical Diseases |
Online Access: | http://europepmc.org/articles/PMC4038472?pdf=render |
Similar Items
-
Pharmacokinetic comparison of different flubendazole formulations in pigs: A further contribution to its development as a macrofilaricide molecule
by: L. Ceballos, et al.
Published: (2015-12-01) -
Exploring flubendazole formulations for use in sheep. Pharmacokinetic evaluation of a cyclodextrin-based solution
by: Ceballos Laura, et al.
Published: (2012-05-01) -
Flubendazole as a macrofilaricide: History and background.
by: Timothy G Geary, et al.
Published: (2019-01-01) -
An In Vitro/In Vivo Model to Analyze the Effects of Flubendazole Exposure on Adult Female Brugia malayi.
by: Maeghan O'Neill, et al.
Published: (2016-05-01) -
In vitro flubendazole-induced damage to vital tissues in adult females of the filarial nematode Brugia malayi
by: Maeghan O'Neill, et al.
Published: (2015-12-01)