Selenium protective activity against aflatoxin B1 adverse affects on Drosophila melanogaster

• Main Authors: Handan Uysal, Güleray Agar
• Format: Article
• Language: English
• Published: Instituto de Tecnologia do Paraná (Tecpar) 2005-03-01
• Series: Brazilian Archives of Biology and Technology
• Subjects: Selenium; Aflatoxin B1; Developmental stages; Protective effect; D. melanogaster
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000200009
• ISSN: 1516-8913; 1678-4324

The aim of this work was to investigate the effects of AFB1 and AFB1+Se4+ on various developmental stages of Drosophila melanogaster were investigated. Both different concentrations of AFB1 and Se4+ applied with AFB1 were fed during the flies developmental period (egg, larva and pupae). When F1 progeny of control and application groups were compared with each other, AFB1 was found to have extending the process of metamorphosis and decreasing the total number of offsprings. But, these negative effects were inhibited with selenium treatment at different concentrations (4.0 and 8.0 ppm). These results suggested that selenium could effectively inhibit AFB1- induced abnormalities of the developmental stages of D.melanogaster.<br>O objetivo deste trabalho foi investigar os efeitos da AFB1 e AFB1 + Se 4 em vários estágios de desenvolvimento da Drosophila melanogaster. Ambos diferentes concentrações da ABF1 e Se4+ aplicado com AFB1 foram alimentados durante a fase de desenvolvimento da mosca (ovo, larva e pulpa). Quando a progenese F1 do controle e aplicações foram comparadas com outros grupos, ABF1 ampliou o processo de metamórfose e na redução do número total de ovos. Porém esses efeitos negativos foram inibidos com o tratamento com selênio em diferentes concentrações (4.0 e 8.0 ppm). Esses resultados sugerem que o selênio pode efetivamente inibir AFB1 que induz anomalias nos estágios do desenvolvimento da Drosophila melanogaster