Molecular Genetics of Pigment Dispersion Syndrome and Pigmentary Glaucoma: New Insights into Mechanisms

Molecular Genetics of Pigment Dispersion Syndrome and Pigmentary Glaucoma: New Insights into Mechanisms

We explore the ideas and advances surrounding the genetic basis of pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG). As PG is the leading cause of nontraumatic blindness in young adults and current tailored interventions have proven ineffective, a better understanding of the underlying...

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Main Authors: Adrian A. Lahola-Chomiak, Michael A. Walter
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Journal of Ophthalmology
Online Access:http://dx.doi.org/10.1155/2018/5926906
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spelling doaj-8953e863b8174580ad0726f7eebf299e2020-11-24T20:58:44ZengHindawi LimitedJournal of Ophthalmology2090-004X2090-00582018-01-01201810.1155/2018/59269065926906Molecular Genetics of Pigment Dispersion Syndrome and Pigmentary Glaucoma: New Insights into MechanismsAdrian A. Lahola-Chomiak0Michael A. Walter1Department of Medical Genetics, Faculty of Medicine, University of Alberta, 8-32 Medical Science Building, Edmonton, AB, CanadaDepartment of Medical Genetics, Faculty of Medicine, University of Alberta, 8-32 Medical Science Building, Edmonton, AB, CanadaWe explore the ideas and advances surrounding the genetic basis of pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG). As PG is the leading cause of nontraumatic blindness in young adults and current tailored interventions have proven ineffective, a better understanding of the underlying causes of PDS, PG, and their relationship is essential. Despite PDS being a subclinical disease, a large proportion of patients progress to PG with associated vision loss. Decades of research have supported a genetic component both for PDS and conversion to PG. We review the body of evidence supporting a genetic basis in humans and animal models and reevaluate classical mechanisms of PDS/PG considering this new evidence.http://dx.doi.org/10.1155/2018/5926906
collection DOAJ
language English
format Article
sources DOAJ
author Adrian A. Lahola-Chomiak
Michael A. Walter
spellingShingle Adrian A. Lahola-Chomiak
Michael A. Walter
Molecular Genetics of Pigment Dispersion Syndrome and Pigmentary Glaucoma: New Insights into Mechanisms
Journal of Ophthalmology
author_facet Adrian A. Lahola-Chomiak
Michael A. Walter
author_sort Adrian A. Lahola-Chomiak
title Molecular Genetics of Pigment Dispersion Syndrome and Pigmentary Glaucoma: New Insights into Mechanisms
title_short Molecular Genetics of Pigment Dispersion Syndrome and Pigmentary Glaucoma: New Insights into Mechanisms
title_full Molecular Genetics of Pigment Dispersion Syndrome and Pigmentary Glaucoma: New Insights into Mechanisms
title_fullStr Molecular Genetics of Pigment Dispersion Syndrome and Pigmentary Glaucoma: New Insights into Mechanisms
title_full_unstemmed Molecular Genetics of Pigment Dispersion Syndrome and Pigmentary Glaucoma: New Insights into Mechanisms
title_sort molecular genetics of pigment dispersion syndrome and pigmentary glaucoma: new insights into mechanisms
publisher Hindawi Limited
series Journal of Ophthalmology
issn 2090-004X
2090-0058
publishDate 2018-01-01
description We explore the ideas and advances surrounding the genetic basis of pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG). As PG is the leading cause of nontraumatic blindness in young adults and current tailored interventions have proven ineffective, a better understanding of the underlying causes of PDS, PG, and their relationship is essential. Despite PDS being a subclinical disease, a large proportion of patients progress to PG with associated vision loss. Decades of research have supported a genetic component both for PDS and conversion to PG. We review the body of evidence supporting a genetic basis in humans and animal models and reevaluate classical mechanisms of PDS/PG considering this new evidence.
url http://dx.doi.org/10.1155/2018/5926906
work_keys_str_mv AT adrianalaholachomiak moleculargeneticsofpigmentdispersionsyndromeandpigmentaryglaucomanewinsightsintomechanisms
AT michaelawalter moleculargeneticsofpigmentdispersionsyndromeandpigmentaryglaucomanewinsightsintomechanisms
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