Hypersensitivity reactions to non beta-lactam antimicrobial agents, a statement of the WAO special committee on drug allergy

• Main Authors: Mario Sánchez-Borges, Bernard Thong, Miguel Blanca, Luis Felipe Chiaverini Ensina, Sandra González-Díaz, Paul A Greenberger, Edgardo Jares, Young-Koo Jee, Luciana Kase-Tanno, David Khan, Jung-Won Park, Werner Pichler, Antonino Romano, Maria José Torres Jaén
• Format: Article
• Language: English
• Published: Elsevier 2013-01-01
• Series: World Allergy Organization Journal
• Online Access: http://www.sciencedirect.com/science/article/pii/S193945511930643X

Antibiotics are used extensively in the treatment of various infections. Consequently, they can be considered among the most important agents involved in adverse reactions to drugs, including both allergic and non-allergic drug hypersensitivity [J Allergy Clin Immunol 113:832–836, 2004]. Most studies published to date deal mainly with reactions to the beta-lactam group, and information on hypersensitivity to each of the other antimicrobial agents is scarce. The present document has been produced by the Special Committee on Drug Allergy of the World Allergy Organization to present the most relevant information on the incidence, clinical manifestations, diagnosis, possible mechanisms, and management of hypersensitivity reactions to non beta-lactam antimicrobials for use by practitioners worldwide.