Synthesis and anti-tuberculosis studies of 10-phenyl sulfonyl-2-alkyl/aryl- 4, 10 dihydrobenzo [4, 5] imidazo [1, 2-a] pyrimidin-4-one derivatives

Synthesis and anti-tuberculosis studies of 10-phenyl sulfonyl-2-alkyl/aryl- 4, 10 dihydrobenzo [4, 5] imidazo [1, 2-a] pyrimidin-4-one derivatives

A series of novel 10-phenylsulfonyl-2-substituted-4,10 dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-one derivatives obtained from N-sulfonation of 2-substituted-pyrimido[1,2-a]benzimidazol-4(10H)-ones and screened for for their in vitro anti-tuberculosis activities against Mycobacterium tuberculosis...

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Main Author: K. V. Jagannath
Format: Article
Language:English
Published: Growing Science 2020-01-01
Series:Current Chemistry Letters
Subjects:
Pyrimido[1
2-a]benzimidazolone
Sulfonamide
Anti-tuberculosis
Single crystal x-ray diffraction
Ionic liquid
Online Access:http://www.growingscience.com/ccl/Vol9/ccl_2019_21.pdf
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spelling doaj-894199c8917c446791c44f9b7447d49b2020-11-24T21:24:23ZengGrowing ScienceCurrent Chemistry Letters1927-72961927-730X2020-01-01911810.5267/j.ccl.2019.6.003Synthesis and anti-tuberculosis studies of 10-phenyl sulfonyl-2-alkyl/aryl- 4, 10 dihydrobenzo [4, 5] imidazo [1, 2-a] pyrimidin-4-one derivativesK. V. JagannathA series of novel 10-phenylsulfonyl-2-substituted-4,10 dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-one derivatives obtained from N-sulfonation of 2-substituted-pyrimido[1,2-a]benzimidazol-4(10H)-ones and screened for for their in vitro anti-tuberculosis activities against Mycobacterium tuberculosis H37Rv by Microplate Alamar Blue Assay (MABA) method. The structures were established on the basis of their IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, ESI-MS data and also the compound with <b>3f</b> were crystallized and analysed by single crystal X-ray diffraction studies. http://www.growingscience.com/ccl/Vol9/ccl_2019_21.pdfPyrimido[12-a]benzimidazoloneSulfonamideAnti-tuberculosisSingle crystal x-ray diffractionIonic liquid
collection DOAJ
language English
format Article
sources DOAJ
author K. V. Jagannath
spellingShingle K. V. Jagannath
Synthesis and anti-tuberculosis studies of 10-phenyl sulfonyl-2-alkyl/aryl- 4, 10 dihydrobenzo [4, 5] imidazo [1, 2-a] pyrimidin-4-one derivatives
Current Chemistry Letters
Pyrimido[1
2-a]benzimidazolone
Sulfonamide
Anti-tuberculosis
Single crystal x-ray diffraction
Ionic liquid
author_facet K. V. Jagannath
author_sort K. V. Jagannath
title Synthesis and anti-tuberculosis studies of 10-phenyl sulfonyl-2-alkyl/aryl- 4, 10 dihydrobenzo [4, 5] imidazo [1, 2-a] pyrimidin-4-one derivatives
title_short Synthesis and anti-tuberculosis studies of 10-phenyl sulfonyl-2-alkyl/aryl- 4, 10 dihydrobenzo [4, 5] imidazo [1, 2-a] pyrimidin-4-one derivatives
title_full Synthesis and anti-tuberculosis studies of 10-phenyl sulfonyl-2-alkyl/aryl- 4, 10 dihydrobenzo [4, 5] imidazo [1, 2-a] pyrimidin-4-one derivatives
title_fullStr Synthesis and anti-tuberculosis studies of 10-phenyl sulfonyl-2-alkyl/aryl- 4, 10 dihydrobenzo [4, 5] imidazo [1, 2-a] pyrimidin-4-one derivatives
title_full_unstemmed Synthesis and anti-tuberculosis studies of 10-phenyl sulfonyl-2-alkyl/aryl- 4, 10 dihydrobenzo [4, 5] imidazo [1, 2-a] pyrimidin-4-one derivatives
title_sort synthesis and anti-tuberculosis studies of 10-phenyl sulfonyl-2-alkyl/aryl- 4, 10 dihydrobenzo [4, 5] imidazo [1, 2-a] pyrimidin-4-one derivatives
publisher Growing Science
series Current Chemistry Letters
issn 1927-7296
1927-730X
publishDate 2020-01-01
description A series of novel 10-phenylsulfonyl-2-substituted-4,10 dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-one derivatives obtained from N-sulfonation of 2-substituted-pyrimido[1,2-a]benzimidazol-4(10H)-ones and screened for for their in vitro anti-tuberculosis activities against Mycobacterium tuberculosis H37Rv by Microplate Alamar Blue Assay (MABA) method. The structures were established on the basis of their IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, ESI-MS data and also the compound with <b>3f</b> were crystallized and analysed by single crystal X-ray diffraction studies.
topic Pyrimido[1
2-a]benzimidazolone
Sulfonamide
Anti-tuberculosis
Single crystal x-ray diffraction
Ionic liquid
url http://www.growingscience.com/ccl/Vol9/ccl_2019_21.pdf
work_keys_str_mv AT kvjagannath synthesisandantituberculosisstudiesof10phenylsulfonyl2alkylaryl410dihydrobenzo45imidazo12apyrimidin4onederivatives
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