Synthesis and anti-tuberculosis studies of 10-phenyl sulfonyl-2-alkyl/aryl- 4, 10 dihydrobenzo [4, 5] imidazo [1, 2-a] pyrimidin-4-one derivatives
A series of novel 10-phenylsulfonyl-2-substituted-4,10 dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-one derivatives obtained from N-sulfonation of 2-substituted-pyrimido[1,2-a]benzimidazol-4(10H)-ones and screened for for their in vitro anti-tuberculosis activities against Mycobacterium tuberculosis...
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| Format: | Article |
| Language: | English |
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Growing Science
2020-01-01
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| Series: | Current Chemistry Letters |
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| Online Access: | http://www.growingscience.com/ccl/Vol9/ccl_2019_21.pdf |
| Summary: | A series of novel 10-phenylsulfonyl-2-substituted-4,10 dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-one derivatives obtained from N-sulfonation of 2-substituted-pyrimido[1,2-a]benzimidazol-4(10H)-ones and screened for for their in vitro anti-tuberculosis activities against Mycobacterium tuberculosis H37Rv by Microplate Alamar Blue Assay (MABA) method. The structures were established on the basis of their IR, <sup>1</sup>H-NMR, <sup>13</sup>C-NMR, ESI-MS data and also the compound with <b>3f</b> were crystallized and analysed by single crystal X-ray diffraction studies. |
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| ISSN: | 1927-7296 1927-730X |