Proteoglycans contribute to the functional integrity of the glomerular endothelial cell surface layer and are regulated in diabetic kidney disease

Proteoglycans contribute to the functional integrity of the glomerular endothelial cell surface layer and are regulated in diabetic kidney disease

Abstract All capillary endothelia, including those of the glomeruli, have a luminal cell surface layer (ESL) consisting of glycoproteins, glycolipids, proteoglycans (PGs) and glycosaminoglycans. Previous results have demonstrated that an intact ESL is necessary for a normal filtration barrier and da...

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Bibliographic Details
Main Authors: Alina Khramova, Roberto Boi, Vincent Fridén, Anna Björnson Granqvist, Ulf Nilsson, Olav Tenstad, Eystein Oveland, Börje Haraldsson, Kerstin Ebefors, Jenny Nyström
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-87753-3

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https://doi.org/10.1038/s41598-021-87753-3

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