Selective spatiotemporal patterns of glial activation and neuron loss in the sensory thalamocortical pathways of neuronal ceroid lipofuscinosis 8 mice

Selective spatiotemporal patterns of glial activation and neuron loss in the sensory thalamocortical pathways of neuronal ceroid lipofuscinosis 8 mice

The neuronal ceroid lipofuscinoses constitute the most common group of childhood neurodegenerative disorders. These devastating disorders still remain without effective treatment. The use of animal models has provided significant information about NCL pathogenesis, highlighting early glial activatio...

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Bibliographic Details
Main Authors: Mervi Kuronen, Anna-Elina Lehesjoki, Anu Jalanko, Jonathan D. Cooper, Outi Kopra
Format: Article
Language:English
Published: Elsevier 2012-09-01
Series:Neurobiology of Disease
Subjects:
Batten disease
Stereology
Neurodegeneration
Thalamus
Gliosis
Lysosomal storage
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112001647

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