At-Risk Populations for Osteosarcoma: The Syndromes and Beyond

At-Risk Populations for Osteosarcoma: The Syndromes and Beyond

Osteosarcoma is the most common primary malignancy of bone. Most cases are sporadic without a known genetic or environmental cause. Heritable genetic predisposition syndromes are associated with a small percentage of osteosarcomas. Study of these rare disorders has provided insight into the molecula...

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Main Authors: George T. Calvert, R. Lor Randall, Kevin B. Jones, Lisa Cannon-Albright, Stephen Lessnick, Joshua D. Schiffman
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Sarcoma
Online Access:http://dx.doi.org/10.1155/2012/152382
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spelling doaj-8915523b32f547708db413c6176307542020-11-24T22:26:22ZengHindawi LimitedSarcoma1357-714X1369-16432012-01-01201210.1155/2012/152382152382At-Risk Populations for Osteosarcoma: The Syndromes and BeyondGeorge T. Calvert0R. Lor Randall1Kevin B. Jones2Lisa Cannon-Albright3Stephen Lessnick4Joshua D. Schiffman5Department of Orthopaedics and Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT 84112, USADepartment of Orthopaedics and Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT 84112, USADepartment of Orthopaedics and Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT 84112, USADivision of Genetic Epidemiology, Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, Utah 84108, USASarcoma Services, Center for Children, Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT 84112, USASarcoma Services, Center for Children, Huntsman Cancer Institute, The University of Utah, Salt Lake City, UT 84112, USAOsteosarcoma is the most common primary malignancy of bone. Most cases are sporadic without a known genetic or environmental cause. Heritable genetic predisposition syndromes are associated with a small percentage of osteosarcomas. Study of these rare disorders has provided insight into the molecular pathogenesis of osteosarcoma. Screening of at-risk families and surveillance of affected individuals for these syndromes may permit earlier diagnosis and more effective treatment of osteosarcoma in these populations. This paper reviews the genetic and clinical features of the known osteosarcoma predisposition syndromes.http://dx.doi.org/10.1155/2012/152382
collection DOAJ
language English
format Article
sources DOAJ
author George T. Calvert
R. Lor Randall
Kevin B. Jones
Lisa Cannon-Albright
Stephen Lessnick
Joshua D. Schiffman
spellingShingle George T. Calvert
R. Lor Randall
Kevin B. Jones
Lisa Cannon-Albright
Stephen Lessnick
Joshua D. Schiffman
At-Risk Populations for Osteosarcoma: The Syndromes and Beyond
Sarcoma
author_facet George T. Calvert
R. Lor Randall
Kevin B. Jones
Lisa Cannon-Albright
Stephen Lessnick
Joshua D. Schiffman
author_sort George T. Calvert
title At-Risk Populations for Osteosarcoma: The Syndromes and Beyond
title_short At-Risk Populations for Osteosarcoma: The Syndromes and Beyond
title_full At-Risk Populations for Osteosarcoma: The Syndromes and Beyond
title_fullStr At-Risk Populations for Osteosarcoma: The Syndromes and Beyond
title_full_unstemmed At-Risk Populations for Osteosarcoma: The Syndromes and Beyond
title_sort at-risk populations for osteosarcoma: the syndromes and beyond
publisher Hindawi Limited
series Sarcoma
issn 1357-714X
1369-1643
publishDate 2012-01-01
description Osteosarcoma is the most common primary malignancy of bone. Most cases are sporadic without a known genetic or environmental cause. Heritable genetic predisposition syndromes are associated with a small percentage of osteosarcomas. Study of these rare disorders has provided insight into the molecular pathogenesis of osteosarcoma. Screening of at-risk families and surveillance of affected individuals for these syndromes may permit earlier diagnosis and more effective treatment of osteosarcoma in these populations. This paper reviews the genetic and clinical features of the known osteosarcoma predisposition syndromes.
url http://dx.doi.org/10.1155/2012/152382
work_keys_str_mv AT georgetcalvert atriskpopulationsforosteosarcomathesyndromesandbeyond
AT rlorrandall atriskpopulationsforosteosarcomathesyndromesandbeyond
AT kevinbjones atriskpopulationsforosteosarcomathesyndromesandbeyond
AT lisacannonalbright atriskpopulationsforosteosarcomathesyndromesandbeyond
AT stephenlessnick atriskpopulationsforosteosarcomathesyndromesandbeyond
AT joshuadschiffman atriskpopulationsforosteosarcomathesyndromesandbeyond
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