Structure-based rational design of a Toll-like receptor 4 (TLR4) decoy receptor with high binding affinity for a target protein.

Structure-based rational design of a Toll-like receptor 4 (TLR4) decoy receptor with high binding affinity for a target protein.

Repeat proteins are increasingly attracting much attention as alternative scaffolds to immunoglobulin antibodies due to their unique structural features. Nonetheless, engineering interaction interface and understanding molecular basis for affinity maturation of repeat proteins still remain a challen...

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Bibliographic Details
Main Authors: Jieun Han, Hyun Jung Kim, Sang-Chul Lee, Seungpyo Hong, Keunwan Park, Young Ho Jeon, Dongsup Kim, Hae-Kap Cheong, Hak-Sung Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3281905?pdf=render

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