Predictive Value of Precision-Cut Kidney Slices as an Ex Vivo Screening Platform for Therapeutics in Human Renal Fibrosis

Predictive Value of Precision-Cut Kidney Slices as an Ex Vivo Screening Platform for Therapeutics in Human Renal Fibrosis

Animal models are a valuable tool in preclinical research. However, limited predictivity of human biological responses in the conventional models has stimulated the search for reliable preclinical tools that show translational robustness. Here, we used precision-cut kidney slices (PCKS) as a model o...

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Bibliographic Details
Main Authors: Emilia Bigaeva, Nataly Puerta Cavanzo, Elisabeth G. D. Stribos, Amos J. de Jong, Carin Biel, Henricus A. M. Mutsaers, Michael S. Jensen, Rikke Nørregaard, Anna M. Leliveld, Igle J. de Jong, Jan-Luuk Hillebrands, Harry van Goor, Miriam Boersema, Ruud A. Bank, Peter Olinga
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Pharmaceutics
Subjects:
renal fibrosis
precision-cut kidney slices
antifibrotic drugs
pirfenidone
galunisertib
imatinib
Online Access:https://www.mdpi.com/1999-4923/12/5/459

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