Mast Cell Activation and Microtubule Organization Are Modulated by Miltefosine Through Protein Kinase C Inhibition

Mast Cell Activation and Microtubule Organization Are Modulated by Miltefosine Through Protein Kinase C Inhibition

Mast cells play an effector role in innate immunity, allergy, and inflammation. Antigen-mediated activation of mast cells initiates signaling events leading to Ca2+ response and the release of inflammatory and allergic mediators from granules. Diseases associated with deregulated mast cell functions...

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Bibliographic Details
Main Authors: Zuzana Rubíková, Vadym Sulimenko, Tomáš Paulenda, Pavel Dráber
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
bone marrow-derived mast cells
cell activation
microtubules
miltefosine
protein kinase C
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01563/full

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