The effect of sex on immune responses to a homocitrullinated peptide in the DR4-transgenic mouse model of Rheumatoid Arthritis

The effect of sex on immune responses to a homocitrullinated peptide in the DR4-transgenic mouse model of Rheumatoid Arthritis

Rheumatoid Arthritis (RA) is more common and severe in women compared to men. Both women and men with RA express autoantibodies to post-translationally modified antigens, including citrullinated and homocitrullinated proteins or peptides. These autoantibodies are strongly linked with the HLA-DR4 gen...

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Bibliographic Details
Main Authors: Ewa Cairns, Sheri Saunders, David A. Bell, Garth Blackler, Patrick Lac, Lillian Barra
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Journal of Translational Autoimmunity
Subjects:
Rheumatoid arthritis
Anti-citrullinated protein/peptide antibodies
Anti-homocitrullinated (carbamylated) protein/peptide antibodies
Sex
Mouse model
Shared epitope
Online Access:http://www.sciencedirect.com/science/article/pii/S2589909020300204

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http://www.sciencedirect.com/science/article/pii/S2589909020300204

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