Posttranscriptional regulation of gene expression – adding another layer of complexity to the DNA damage response

Posttranscriptional regulation of gene expression – adding another layer of complexity to the DNA damage response

In response to DNA damage, cells activate a complex, kinase-based signaling network to arrest the cell cycle and allow time for DNA repair, or, if the extend of damage is beyond repair capacity, induce apoptosis. This signaling network, which is collectively referred to as the DNA damage response (D...

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Bibliographic Details
Main Authors: Jorge eBoucas, Katja eHöpker, Shuhua eChen, Grit Sophie Herter-Sprie, Mladen eJokic, Arina eRiabinska, Hans Christian Reinhardt
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Genetics
Subjects:
Cell Cycle Checkpoints
RNA-Binding Proteins
DNA damage response
HuR
p38MAPK
MAPKAP-kinase 2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00159/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00159/full

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