The Length of Hydrophobic Chain in Amphiphilic Polypeptides Regulates the Efficiency of Gene Delivery

The Length of Hydrophobic Chain in Amphiphilic Polypeptides Regulates the Efficiency of Gene Delivery

The major challenges of non-viral carriers are low transfection efficiency and high toxicity. To overcome this bottleneck, it is very important to investigate the structure-property-function (transfection efficiency) relationships of polycations. Herein, different length hydrophobic poly(l-leucine)...

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Bibliographic Details
Main Authors: Ying Zhang, Zhiping Zhou, Mingsheng Chen
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Polymers
Subjects:
controlled polymerization
biocompatible polypeptides
gene delivery
transfection efficiency
hydrophobic chain
structure-property-function
Online Access:http://www.mdpi.com/2073-4360/10/4/379

Internet

http://www.mdpi.com/2073-4360/10/4/379

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