Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature

Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature

Alteration of cerebrospinal fluid (CSF) flow and cilia defects are clinically associated with idiopathic scoliosis. This study shows that transient receptor potential channel Pkd2l1 is required for mechanosensory function of neurons detecting CSF flow and normal spine curvature development in zebraf...

Full description

Bibliographic Details
Main Authors: Jenna R. Sternberg, Andrew E. Prendergast, Lucie Brosse, Yasmine Cantaut-Belarif, Olivier Thouvenin, Adeline Orts-Del’Immagine, Laura Castillo, Lydia Djenoune, Shusaku Kurisu, Jonathan R. McDearmid, Pierre-Luc Bardet, Claude Boccara, Hitoshi Okamoto, Patrick Delmas, Claire Wyart
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06225-x
id doaj-88d9999b54c84d7280f863923497f69e
record_format Article
spelling doaj-88d9999b54c84d7280f863923497f69e2021-05-11T09:25:54ZengNature Publishing GroupNature Communications2041-17232018-09-019111010.1038/s41467-018-06225-xPkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvatureJenna R. Sternberg0Andrew E. Prendergast1Lucie Brosse2Yasmine Cantaut-Belarif3Olivier Thouvenin4Adeline Orts-Del’Immagine5Laura Castillo6Lydia Djenoune7Shusaku Kurisu8Jonathan R. McDearmid9Pierre-Luc Bardet10Claude Boccara11Hitoshi Okamoto12Patrick Delmas13Claire Wyart14Sorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, AP-HP, Institut du Cerveau et de la Moelle épinière (ICM) - Hôpital Pitié-SalpêtrièreSorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, AP-HP, Institut du Cerveau et de la Moelle épinière (ICM) - Hôpital Pitié-SalpêtrièreAix Marseille Université, CNRS, Laboratoire de Neurosciences Cognitives-UMR7291Sorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, AP-HP, Institut du Cerveau et de la Moelle épinière (ICM) - Hôpital Pitié-SalpêtrièreSorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, AP-HP, Institut du Cerveau et de la Moelle épinière (ICM) - Hôpital Pitié-SalpêtrièreSorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, AP-HP, Institut du Cerveau et de la Moelle épinière (ICM) - Hôpital Pitié-SalpêtrièreAix Marseille Université, CNRS, Laboratoire de Neurosciences Cognitives-UMR7291Sorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, AP-HP, Institut du Cerveau et de la Moelle épinière (ICM) - Hôpital Pitié-SalpêtrièreRiken Brain Science InstituteDepartment of Neuroscience, Psychology & Behaviour, College of Medicine, Biological Sciences and Psychology, University of LeicesterSorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, AP-HP, Institut du Cerveau et de la Moelle épinière (ICM) - Hôpital Pitié-SalpêtrièrePSL Research University, Institut Langevin, ESPCI ParisRiken Brain Science InstituteAix Marseille Université, CNRS, Laboratoire de Neurosciences Cognitives-UMR7291Sorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, AP-HP, Institut du Cerveau et de la Moelle épinière (ICM) - Hôpital Pitié-SalpêtrièreAlteration of cerebrospinal fluid (CSF) flow and cilia defects are clinically associated with idiopathic scoliosis. This study shows that transient receptor potential channel Pkd2l1 is required for mechanosensory function of neurons detecting CSF flow and normal spine curvature development in zebrafish.https://doi.org/10.1038/s41467-018-06225-x
collection DOAJ
language English
format Article
sources DOAJ
author Jenna R. Sternberg
Andrew E. Prendergast
Lucie Brosse
Yasmine Cantaut-Belarif
Olivier Thouvenin
Adeline Orts-Del’Immagine
Laura Castillo
Lydia Djenoune
Shusaku Kurisu
Jonathan R. McDearmid
Pierre-Luc Bardet
Claude Boccara
Hitoshi Okamoto
Patrick Delmas
Claire Wyart
spellingShingle Jenna R. Sternberg
Andrew E. Prendergast
Lucie Brosse
Yasmine Cantaut-Belarif
Olivier Thouvenin
Adeline Orts-Del’Immagine
Laura Castillo
Lydia Djenoune
Shusaku Kurisu
Jonathan R. McDearmid
Pierre-Luc Bardet
Claude Boccara
Hitoshi Okamoto
Patrick Delmas
Claire Wyart
Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature
Nature Communications
author_facet Jenna R. Sternberg
Andrew E. Prendergast
Lucie Brosse
Yasmine Cantaut-Belarif
Olivier Thouvenin
Adeline Orts-Del’Immagine
Laura Castillo
Lydia Djenoune
Shusaku Kurisu
Jonathan R. McDearmid
Pierre-Luc Bardet
Claude Boccara
Hitoshi Okamoto
Patrick Delmas
Claire Wyart
author_sort Jenna R. Sternberg
title Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature
title_short Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature
title_full Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature
title_fullStr Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature
title_full_unstemmed Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature
title_sort pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-09-01
description Alteration of cerebrospinal fluid (CSF) flow and cilia defects are clinically associated with idiopathic scoliosis. This study shows that transient receptor potential channel Pkd2l1 is required for mechanosensory function of neurons detecting CSF flow and normal spine curvature development in zebrafish.
url https://doi.org/10.1038/s41467-018-06225-x
work_keys_str_mv AT jennarsternberg pkd2l1isrequiredformechanoceptionincerebrospinalfluidcontactingneuronsandmaintenanceofspinecurvature
AT andreweprendergast pkd2l1isrequiredformechanoceptionincerebrospinalfluidcontactingneuronsandmaintenanceofspinecurvature
AT luciebrosse pkd2l1isrequiredformechanoceptionincerebrospinalfluidcontactingneuronsandmaintenanceofspinecurvature
AT yasminecantautbelarif pkd2l1isrequiredformechanoceptionincerebrospinalfluidcontactingneuronsandmaintenanceofspinecurvature
AT olivierthouvenin pkd2l1isrequiredformechanoceptionincerebrospinalfluidcontactingneuronsandmaintenanceofspinecurvature
AT adelineortsdelimmagine pkd2l1isrequiredformechanoceptionincerebrospinalfluidcontactingneuronsandmaintenanceofspinecurvature
AT lauracastillo pkd2l1isrequiredformechanoceptionincerebrospinalfluidcontactingneuronsandmaintenanceofspinecurvature
AT lydiadjenoune pkd2l1isrequiredformechanoceptionincerebrospinalfluidcontactingneuronsandmaintenanceofspinecurvature
AT shusakukurisu pkd2l1isrequiredformechanoceptionincerebrospinalfluidcontactingneuronsandmaintenanceofspinecurvature
AT jonathanrmcdearmid pkd2l1isrequiredformechanoceptionincerebrospinalfluidcontactingneuronsandmaintenanceofspinecurvature
AT pierrelucbardet pkd2l1isrequiredformechanoceptionincerebrospinalfluidcontactingneuronsandmaintenanceofspinecurvature
AT claudeboccara pkd2l1isrequiredformechanoceptionincerebrospinalfluidcontactingneuronsandmaintenanceofspinecurvature
AT hitoshiokamoto pkd2l1isrequiredformechanoceptionincerebrospinalfluidcontactingneuronsandmaintenanceofspinecurvature
AT patrickdelmas pkd2l1isrequiredformechanoceptionincerebrospinalfluidcontactingneuronsandmaintenanceofspinecurvature
AT clairewyart pkd2l1isrequiredformechanoceptionincerebrospinalfluidcontactingneuronsandmaintenanceofspinecurvature
_version_ 1721449896414806016

Similar Items